Dequalinium chloride CAS: 522-51-0
26-05-2023
522-51-0 - Physico-chemical Properties
| Molecular Formula | C30H40Cl2N4
|
| Molar Mass | 527.57 |
| Melting Point | ≥300°C(lit.) |
| Solubility | Slightly soluble in water and in ethanol (96 per cent). |
| Appearance | neat |
| Color | Beige |
| Merck | 13,2930 |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| Use | Broad-spectrum antibacterial drugs for acute pharyngitis, oral Disinfection |
| In vitro study | Dequalinium chloride (DECA) is a cationic lipophilic compound with a structure similar to the dye Rhodamine 123. DECA selectively accumulates and is retained in the mitochondria of tumor cells, where it acts as a mitochondrial poison by blocking mitochondrial enzymes and subsequently disrupts cellular energy production, ultimately leading to cell death. Dequalinium Chloride is a ganglion conduction blocker (EC50=2 μm). Dequalinium is a potent inhibitor of potassium channels in melittin-sensitive hepatocytes and of nicotine response in skeletal muscle. Dequalinium blocks angiotensin II-induced potassium loss with an IC50 of 1.5 μm and inhibits Dequalinium-sensitive posterior hyperpolarization (AHP) in cultured rat sympathetic neurons the component can be rapidly and reversibly inhibited, followed by the generation of a single action potential. Dequalinium Chloride (DECA) is a cationic lipophilic PKC inhibitor. When exposed to UV light, DECA covalently binds and reversibly inhibits PKC α and PKC β. |
| In vivo study | In mice bearing bladder MB49 tumors, Dequalinium chloride (2 mg/kg/d, I. p.) showed anticancer activity with a T/C of 210%. |
522-51-0 - Reference Information
| biological activity | Dequalinium Chloride is a PKC inhibitor with an IC50 of 7-18 μM, and is also a selective bee toxin peptide sensitive potassium channel blocker with an IC50 of 1.1 μM. |
| Target | Value |
| PKC | 7 μM-18 μM |
| use | broad-spectrum antibacterial drugs for acute pharyngitis, oral disinfection, etc. |
Get the latest price? We'll respond as soon as possible(within 12 hours)
